Of the 16, seven people were hospitalized and one developed kidney failure.
Of the eight people interviewed by health officials, six reported tasting or eating raw batter made with cake mix.
Those interviewed reported buying different varieties and brands of cake mix; the FDA is conducting an investigation to see if there is any common brand or production facility connected with the illnesses.
Those who became ill range in age from 2 to 73 years old, with a median age of 13, and all are female. No deaths have been reported.
The CDC said the true number of sick people is “likely much higher than the number reported” and could stretch across other states.
Officials reminded Americans to avoid eating raw batter — regardless of where it comes from.
According to the CDC, raw cake batter contains harmful germs like E.coli, which are killed only when the batter is baked or cooked. The CDC urges that people follow safe food handling practices when baking and cooking with cake mixes, flour and other raw ingredients such as eggs.