The shooting happened in a courtyard at the Wagner Houses at 120th Street near First Avenue around 1 a.m.
One of the men was shot in the head and was pronounced dead at NYC Health + Hospitals/Harlem. The other victim was shot in the torso and is expected to survive.
A third man involved in the shooting fled the scene, and police are searching for him.
Police are unsure what sparked the incident.
Both men were taken to NYC Health + Hospitals/Harlem.
PIX11 News spoke to a woman who identified herself as the deceased victim's aunt. She says the men, who are cousins, were at a basketball tournament.
Detectives and the Crime Scene Unit remained on the scene near First Avenue and East 122nd Street.AlertMe