"Melania Trump said, 'the strength of your dreams and your willingness to work for them.' Twilight Sparkle from 'My Little Pony' said, 'this is your dream. Anything you can do in your dreams, you can do now,'" he said.
Shortly after the interview, "My Little Pony" became one of the top trends on Twitter.
Comedian Patton Oswalt tweeted, "Sean Spicer-- ironically is the perfect name for a my little pony character who was cool with plagiarism."
Zach Braff wrote, "My little pony is trending. What a time to be alive."
Another person tweeted, "Rick Astley, Milli Vanilli, My little pony.. sounds like one political party has 80's nostalgia."
But one Twitter user is blaming all the controversy on another pony, tweeting, "It's probably THIS my little pony's fault #rainbowdash."
"If we want to take a bunch of phrases and run them through Google, and say who else has said them, I can come up with a list in 5 minutes," Spicer said.